J Mol
115
Cell
Cardiol
22 (Supplement
IV)
(1990)
EFFECTS OF TREATMENT WITH SUPEROXIDE DISMUTASE AND CATALASE ON MYOCARDIAL INFARCT Fiona H. McDonald. Research Laboratories of Schering AG, SIZE IN TEE PIG. Postfach 650311, D-1000 Berlin 65. West Germany There is still considerable controversy over the role of oxygen free radicals in the pathogenesis of injury resulting from myocardial ischaemia and reperfusion. In we have investigated the effects of superoxide dismutase (SOD) and catathis study, lase (Cat) treatment on infarct size following coronary artery occlusion and reperfusion in the pig. Anaesthetised open-chest pigs were subjected to occlusion of the left anterior descending coronary artery for 60 or 90min, followed by reperfusion for 2h. Area at risk was then visualised in viva with disulphine blue and infarcted tissue by tetrazolium staining. Treated animals received a total dose of SOD of 33,33OU/kg and Cat 58O,OOOU/kg as bolus injections pre-occlusion and pre-reperfusion and an infusion over the first 60min of reperfusion. Control animals received an appropriate volume of solvent. In most animals, the treatment was haemodynamically inert. Area at risk was similar in all 4 groups (C60: 16.9 f0.9, SOD/CatbO: 13.5 f2.0, c90: 16.8 fl.1, SOD/Cat90: 22.1 i2.02 of ventricular mass, n-3-6/group). Infarct size (as X of area at risk) after 6Omin ischaemia was 70.5 f .6 in control after 90min ischaemia it was 83.3 fl.O in controls and pigs and 68.8 f3.4 in SOD/Cat; 88.0 f5.7 in SOD/Cat-treated animals. Therefore, in this model of ischaemia-reperr'usion induced injury, superoxide and/or E202 do not seem to play a major role in the pathogenesis of tissue damage.
ATRIAL TACRYCARDIA PER SE INDUCES ATRIAL NATRIURBTIC FACTOR RELEASE DESPITE ATRIAL PRRSSURB DECREASE. A. Mebazaa, G. Maistre, J. Mateo, D. LariboisiPre University Hospital, Paris, France. Payen, of Atria1 Tachycardia (AT)-induced plasma Atria1 The mechanisms Natriuretic Factor (pANF) release are not Clear Since transmural right atria1 (RAPTm) and pulmonary capillary wedge pressures (PcwFTm) are also increased. In order to eliminate this latter effect, we measured in 7 patients (60 f 9 yrs), 6 hours after coronary mean surgery, arterial pressure (MAP): IUPTm, PcwPTm (Swan-Ganz KT, esophageal pANF (RIA, Normal value : 48 + 12 pg/ml). Protocol : balloon): control (Cl); 30 min after lower body positive pressure application LBPP deflation followed by 5 min atria1 tachycardia ( pacing) (LSPP)i to decrease RAPTm and PcwPTm during AT (AT): 45 min after AT (C2). LBPP AT c2 Cl 150 f 16 $ RR (b/min) 84 + 16 79 + 8 77 f 10 $ 142 + 79 377 + 245 * 67; ; 90; $ 326 f 218 $ Pm (pghl) 2.2 + 2.6 11.5 + 4 $ 5 f 2.3 RAPTm miaw) 3.2 f 4.9 14 * 3.9 $ 10.5 f 4 $ 6.4 f 4.4 PcwPTm (mmHg). 81?: 27 $ 95 2 22 83 f 20 100 f 23 $ HAP mam * px.05, $ pc.01 Vs previous set (mean f SD). The direct stimulating effect of AT is demonstrated.
117
METABOLIC EVOLUTION OF A HUMAN HEART DURING 24 HOURS COLD STORAGE ,*[email protected] P, **Girard C., *Songadele cl A. l *Dureau G., **Chuzel M. l *Estanove 8, *Freminet A. Zervica Physiolcgie Metaboltsme lntermediaire et Eneretique. Universite Lyon I and Hopital Cardiolcgique Louis Pradel Lyon - France. A human heart arrested by a flush of one liter of St Thomas Hospital solution and stored at 4°C was not transplanted owmq to serological reasons (Hbs+ ). After 3. 6. 12 or 24 h of cold storage. Tmsue samples were frozen in liquid ntkogen and cardiac metabolites were measured either by luminometric or Sph9drOphOtOIII8triC met hats. Time ATP ADP AMP CP IA EC Glc G6P Lact Lact/Pyr Wcogen 3h 5.9 I.0 1.4 0.7 8.3 0.77 64 0.1 0.1 8.8 46 , 6h 4.3 1.3 0.5 0.2 6.5 0.76 42 0.4 1.3 22.0 67 12h 2.7 1 2.3 1 I.7 1 0.2 1 6.7 1 0.58 1 42 [ 0.4 1 I.2 1 16.7 1 98 24 h 1 1.4 1 1.0 I 1.6 I 0 1 4.0 1 0.47 1 39 1 0.5 1 1.0 1 18.8 1 209 1 = ATP + ADP+ANP, EC= ATP + 0.5 ADP/XA, Results in umollq wet wetqht. From these results it appears, that thought EC is.rather will preserved during the first 12 h of cold storage. inhibition of glyaqsnolysis and glycolysis is obvious as soon as the 6th hour of wld storage. It is suggested lhat the admlnistratlon of a second dose of cardtoplegic solution after the 3d hour of cold storage might be of Interest III order to prevent thts tnhfbttton s.39

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A Cold Heart PDF Details

Author:	Jonathan Kellerman
Original Title:	A Cold Heart
Book Format:	Paperback
Number Of Pages:	413 pages
First Published in:	April 29th 2003
Latest Edition:	December 30th 2003
Series:	Alex Delaware #17
Language:	English
Main Characters:	Alex Delaware
category:	mystery, fiction, thriller, mystery, crime, thriller, mystery thriller, suspense, psychology, mystery, detective, mystery, murder mystery, audiobook
Formats:	ePUB(Android), audible mp3, audiobook and kindle.

The translated version of this book is available in Spanish, English, Chinese, Russian, Hindi, Bengali, Arabic, Portuguese, Indonesian / Malaysian, French, Japanese, German and many others for free download.

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